Keynote Speaker: Vincent Delatour
Prinicipal Investigator Biomarkers / Bioanalysis at LNE (French Metrology Laboratory)
Vincent obtained his Engineer degree in Biotechnology in 2003 (INSA Lyon, France). He did his PhD thesis in exploratory Oncology in the lab of Marie-France Carlier in CNRS (Gif sur Yvette, France), where he studied cell motility through the development of a biomimetic system based on purified proteins and liposomes. This project – funded by a Human Frontiers Grant – was at the interface between biochemistry, biophysics and physico-chemistry. After completing his PhD in 2007, he joined LNE – the French National Metrology Institute – to work on the development of reference methods for the absolute quantification of biomarkers by mass spectrometry. After his postdoctoral fellow, Vincent became the group leader of a new research group in bioanalysis, the objective of which being to develop reference methods for the measurement of clinically relevant biomarkers and produce the associated certified reference materials. The goal of this work is to assess and improve the performance and the comparability of routine methods used in medical laboratories to measure a large panel of biomarkers associated with pathologies such as diabetes mellitus, kidney disease, cardiovascular disease, neurodegenerative disorders. Vincent coordinates research projects in metrology at the National and the European Level. Vincent is a member of the French Society of Clinical Biology (SFBC), the European Atherosclerosis Society (EAS), the Lipoprotein and Vascular Disease Division of the American Association for clinical Chemistry (LVDD-AACC). He’s also a member of the IFCC (International Federation of Clinical Chemistry) working groups on commutability (WG-C) and on Clinical Mass Spectrometry Proteomics (WG-cMSP). He’s an expert for the French National Agency for Medicines and Health Products Safety (ANSM) and for the French National Authority for Health (HAS). His areas of expertise are : metrology, traceability and standardization in laboratory medicine, production and certification of international standards, performance assessment of technologies, evaluation of medico-economic impact, absolute quantification of metabolites, peptides and proteins by mass spectrometry, advanced lipoprotein testing, purification techniques, calibration strategies, measurement uncertainty calculation, commutability assessment
Abstract: : Commutable certified reference materials for next generation accuracy-based EQA schemes
Although reference method target values are necessary to estimate methods trueness, another prerequisite is needed: quality control materials must be commutable, ie. mimic the behavior of patient samples. In contrary to authentic clinical specimens (that are commutable by definition), External Quality Assessment materials can be subject to matrix effects that are due to the different treatments applied to the materials during their preparation (eg. lyophilization, freezing, addition of preservatives and/or cryoprotectants, pooling, spiking with exogenous chemicals or purified compounds to increase concentration). Non commutability of EQA materials may skew trueness assessment because the difference between the reference method target value and the measured value will actually correspond to the sum of the analytical bias (that is due to the method itself) and the bias due to matrix effects (that is due to sample non-commutability). Given that non commutability can affect some methods more than others (a material could be commutable for one method but not for another one), non-commutability of EQA materials can also compromise the ability to evaluate the agreement between the different methods. In this presentation, the concept of commutability will be explained and the latest IFCC recommendations will be presented with the objective to highlight the potential role of commutable certified reference materials in next generation accuracy-based EQA schemes.
International Congress on Quality in Laboratory Medicine
Welcome to the International Congress on Quality in Laboratory Medicine 7-8 February 2019 Helsinki. The inspiring atmosphere of the scientific congress brings medical laboratory and quality management professionals together to exchange ideas and meet colleagues. The 2019 themes are Quality Control Reinvented? and Digital Health. Two inspiring days with world class speakers guarantees an unforgettable experience.
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